Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (4): 172-175.doi: 10.3969/j.issn.1004-616x.1999.04.005

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NORMALIZING OF xylE-ICR TRANSGENIC MOUSE MODELS FOR MEASURINGMUTATIONS IN VIVO

Yang Zhifeng , Huang J ian , Zheng Yiwen , Chen Yaofu , Yi Muquan   

  1. Department of Hygienic Toxicology , Second Military Medical University , S hanghai  200433
  • Received:1900-01-01 Revised:1900-01-01 Online:1999-07-30 Published:1999-07-30

Abstract: Allow MNNG administ ration in the xylE2ICR t ransgenic mice. We dosed for 5 days , then count survivors 21 days after the final dose. The result s showed : the spontaneous mutant f requency for xylE gene in the liver of xylE-ICR t ransgenic mice was much lower than the MNN G2induced mutant frequency. It is evident that the protocol could be used in the analysis of mutagenesis of chemicals.

Key words: transgenic mouse, mutagenesis, normalizing